IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia

IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia

Background  Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal administration of intravenous immunoglobulin (IVIG) therapy and prednisone according to protocols based on risk stratification. While IVIG is generally well tolerated, hematologic side effects are a potential complication. Case  We present the successful management of a rare complication of materna...

Prediction of IVIG treatment efficiency in fetal/neonatal alloimmune thrombocytopenia.

Prediction of IVIG treatment efficiency in fetal/neonatal alloimmune thrombocytopenia Fetal/neonatal alloimmune thrombocytopenia resulting from specific maternal immunization against human platelet antigens (HPAs) is the most frequent cause of severe isolated thrombocytopenia (platelet counts ,50 3 10 9 /L) in maternity wards, and its most destructive consequence is intracranial hemorrhage (20%...

Neonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia.

Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...

Neonatal alloimmune thrombocytopenia.

Neonatal alloimmune thrombocytopenia: current considerations.

Some mothers produce antibodies to the platelet antigens of their fetuses. Exposure to these antigens may occur owing to prior transfusions or through feto-maternal hemorrhage during gestation or delivery. The sensitizing antigen is usually an epitope of one of the glycoproteins (GP) found on the platelet membrane. Specific GPs act as receptors for factors important in hemostasis, such as von W...